Study of Tissue Repair in Inflammatory Bowel Disease Exploiting Organoid Technology

Launched by ASSISTANCE PUBLIQUE HOPITAUX DE MARSEILLE · Jan 28, 2025

Keywords

ClinConnect Summary

This clinical trial is investigating how certain cells in the intestines of patients with Inflammatory Bowel Disease (IBD), like Crohn's Disease and Ulcerative Colitis, respond to inflammation and repair themselves. Researchers want to understand why these cells might heal poorly compared to cells from non-inflamed areas of the same patient or from healthy individuals. By studying small samples of tissue (called organoids) derived from patients, the team hopes to identify the differences in how these cells behave when faced with inflammation. This could help improve treatment strategies for IBD in the future.

To participate in this study, individuals must be 18 years or older and have either Crohn’s Disease or Ulcerative Colitis. They should be undergoing a colonoscopy for their condition. Healthy volunteers who have no history of IBD but are having a colonoscopy for other reasons may also be included in the study. Participants can expect to provide tissue samples during their colonoscopy, which will be analyzed in the lab. The findings from this research could lead to better understanding and management of IBD.

Gender

ALL

Eligibility criteria

• For IBD group the inclusion criteria will be:
• • Patients of either sex aged 18 years or older
• • Patient that have read the information form and signed consent
• • Patient covered with health insurance
• • Patients with Crohn's Disease or ulcerative colitis in accordance with accepted clinical, endoscopic, histological and/or radiologic criteria, regardless of the level, severity of the disease or duration of disease progression.
• • Patients with colonic involvement of Crohn's disease or ulcerative colitis
• • Patients undergoing a screening colonoscopy in the context of IBD disease follow-up OR undergoing intestinal resection for IBD disease aggravation
• For control group the inclusion criteria will be:
• • Patients of either sex aged 18 years or older
• • Patient that have read the information form and signed consent
• • Patient covered with health insurance
• • Patients undergoing a screening colonoscopy in the context of a family history of colonic neoplasia, follow-up of colonic polyps or functional intestinal disorders OR undergoing intestinal resection for intestinal neoplasia, occlusive syndrome or colostomy
• The non-inclusion criteria for IBD group will be:
• • Contraindication to the anaesthetic or colonoscopy procedure
• • Patients without colonic involvement of Crohn's disease or ulcerative colitis
• • Patients of Adults without legal capacity
• • Patients in Health and Social Establishments
• • Persons in emergency situations
• • Persons deprived of their liberty
• • Non-affiliated to a social security scheme
• • Absence or refusal of the informed consent
• The non-inclusion criteria for control group will be:
• • IBD disease revealed during colonoscopy or gastrointestinal resection
• • Patient suffering from Immune-Mediated Inflammatory Diseases (IMIDs)
• • Contraindication to the anaesthetic or colonoscopy procedure
• • Patients of Adults without legal capacity
• • Patients in Health and Social Establishments
• • Persons in emergency situations
• • Persons deprived of their liberty
• • Non-affiliated to a social security scheme
• • Absence or refusal of the informed consent