Flu Infection at UPHS

Launched by UNIVERSITY OF PENNSYLVANIA · Jan 29, 2025

Keywords

ClinConnect Summary

This clinical trial, titled "Flu Infection at UPHS," is studying how the immune system responds to influenza, commonly known as the flu, in people who are currently infected. Researchers want to understand if people’s immune systems rely more on existing memory responses from past infections or vaccinations, rather than creating new responses when they get sick with the flu. The study is currently looking for up to 50 participants each year who are at least 18 years old and have tested positive for the flu within the University of Pennsylvania Health System.

To join the study, participants must agree to follow the study guidelines and provide written consent. However, certain individuals are excluded, such as those with specific medical conditions that could interfere with the study or those who are pregnant. If you participate, you can expect to provide some blood samples, as the researchers will be assessing your immune responses. This trial is an important step in understanding how our bodies fight the flu and could help improve future treatments and vaccines.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Provision of signed and dated informed consent form
• • 2. Stated willingness to comply with all study procedures and availability for the duration of the study
• • 3. Aged 18 years and older
• • 4. Influenza positive test result performed within the University of Pennsylvania Health System
• Exclusion Criteria:
• • 1. Known latex allergy
• • 2. Immunosuppression as a result of an underlying illness or treatment with immunosuppressive or cytotoxic drugs, or use of anticancer chemotherapy or radiation therapy within the preceding 36 months
• • 3. Pregnancy due to the volume of blood collected in this study
• • 4. Treatment with immunoglobulin or another blood product within the 3 months prior to enrollment in this study
• • 5. Any neoplastic disease (excluding non-melanoma skin cancer or prostate cancer that is stable in the absence of therapy) or a history of any hematological malignancy ("active" is defined as having received treatment within the past 5 years)
• • 6. Known acute or chronic medical condition that, in the opinion of the investigator or appropriate sub-investigator, would interfere with the evaluation of immune responses
• • 7. Intends to donate blood during the study period
• • 8. A known human immunodeficiency virus, hepatitis B, or hepatitis C infection
• • 9. Any condition that would, in the opinion of the site investigator, place the subject at an unacceptable risk of injury or render the subject unable to meet the requirements of the protocol
• • 10. Prolonged inpatient hospitalization that disrupts or interferes with study procedures.
• • 11. Weigh less than 110lbs