Comparison of Two Cognitive-Motor Rehabilitation Approaches Via Exergames: a Study of Cognitive, Motor and Behavioral Functions in Huntington's Disease Patients

Launched by UNIVERSITY HOSPITAL, ANGERS · Jan 29, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at two different ways to help people with Huntington's disease (HD) improve their thinking, movement, and behavior. Huntington's disease is a genetic condition that usually appears in middle age and causes problems with movement, memory, and emotions. Since there isn't a cure for HD, researchers are exploring new methods to help manage symptoms. In this study, they will compare a program that combines physical exercise and mental challenges (called exergames) with a more traditional step-by-step approach to treatment.

To be part of this trial, participants need to be adults who have been diagnosed with early stages of Huntington's disease and meet certain health criteria. They should be able to understand the study and provide consent. Participants can expect to engage in activities that might help improve their quality of life, and the study aims to gather information on how effective these new approaches are. It's important to note that people with certain medical conditions or who are pregnant won't be able to participate. The trial is not yet recruiting, but it represents an exciting opportunity to explore new ways to support individuals living with Huntington's disease.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adults at inclusion
• • Huntington's disease diagnosed and confirmed by genetic analysis
• • Patient with stage 1-2 HD with a motor UHDRS score ≥ 5 and a CFT between 6 \< CFT ≤ 13
• • Patient with written informed consent or third-party consent
• • Affiliated or beneficiary of a social security scheme
• Exclusion Criteria:
• • Poor understanding of the French language
• • Participation in interventional research modifying management
• • History likely to interfere with cognition (established stroke, sequelae of traumatic brain injury, active epilepsy, learning disorders, alcohol dependence syndrome, drug use, psychiatric disorders), severe cognitive deficit (MMSE \<16), clinically significant pathological condition which, in the investigator's opinion, could interfere with the subject's safety or the evaluation of study results
• • Pregnant or breast-feeding women
• • Persons deprived of their liberty by administrative or judicial decision
• • Persons under compulsory psychiatric care