Comparison Between Efficacy of Topical 25%Podophyllin and Cryotherapy on Genital Warts

Launched by SHEIKH ZAYED MEDICAL COLLEGE · Jan 30, 2025

Keywords

ClinConnect Summary

This clinical trial is comparing two treatments for genital warts caused by the human papilloma virus (HPV). The study will look at how effective a topical treatment called 25% podophyllin is, compared to a procedure called cryotherapy, which freezes the warts. Both treatments will be given over four weeks, with participants receiving either the topical treatment once a week or the cryotherapy twice a week. The goal is to see which treatment leads to a more significant reduction in the number of warts.

To participate in the trial, individuals must be between 16 and 60 years old and have been diagnosed with genital warts. They should have up to 20 warts, each covering less than 10 square centimeters in total. However, pregnant or breastfeeding women, people with certain health conditions, or those who have had recent treatments for warts will not be eligible. Participants can expect to have follow-up visits to assess the effectiveness of the treatments, with results graded based on how many warts have cleared up. This trial aims to find the best way to treat genital warts, which affects many people worldwide.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age: 16-60years
• • Gender: Any gender
• • All new clinically diagnosed cases of plane warts
• • Type of warts: plane warts
• • Area: Ano-genital warts
• • Size: Less than 10cm2(cummulative)
• • No. of warts: Upto 20
• • Duration of disease: Any
• Exclusion Criteria:
• • Pregnancy and lactating females
• • Bleeding disorders
• • Immunocompromised patients.
• • Diabetic patients / Peripheral vascular disease.
• • Bleeding warts, moles, birthmarks.
• • Any other inflammatory dermatosis on that area
• • History of any previous treatment in last 2 months.
• • Liver/Renal disease
• • Hypersensitivity to Podophyllin.