Comparison Between Intravenous Ondanosteron and Metclopromide Versus Ondanesteron and Dexamethasone Effects on the Prevention of Postoperative Nausea and Vomiting in Cesarean Section

Launched by AIMAN AL-TOUNY · Jan 30, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how well two different combinations of medications can prevent nausea and vomiting after a cesarean section surgery. The trial compares one group receiving ondansetron and dexamethasone to another group receiving ondansetron and metoclopramide. Both combinations aim to reduce the chances of feeling sick during and after surgery, particularly in the first 24 hours.

Women aged 18 to 40 years who are scheduled for an elective cesarean section under spinal anesthesia may be eligible to participate. To join, they should be in good health (ASA II or III) and have not eaten solid food for 8 hours or consumed water for 2 hours before the procedure. Participants will be randomly assigned to one of the two medication groups and will be monitored for any nausea or vomiting during their recovery. It's important for potential participants to know that certain health conditions and histories, such as severe obesity or previous allergies to the study drugs, may exclude them from taking part in this trial.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • 1. ASA II and III pregnant patients scheduled for elective C.S under spinal anesthesia
• • 2. Age 18-40 years
• • 3. Fasting before the procedure for 8 hours from solid food intake and 2 hours from water intake
• Exclusion Criteria:
• • 1. Patients with ASA physical status \> III.
• • 2. BMI \>35.
• • 3. History of motion sickness and extrapyramidal disease.
• • 4. Smokers.
• • 5. History of allergy to any of involved drugs in the study.
• • 6. Patients developed nausea and vomiting and/or received antiemetic drugs within 24 hours prior to surgery.
• • 7. History of hyperemesis gravidarum.
• • 8. History of peptic ulcer disease.