Trifecta Research Study

Launched by JOHNS HOPKINS UNIVERSITY · Feb 4, 2025

Keywords

ClinConnect Summary

The Trifecta Research Study is looking into new treatments for veterans who have experienced combat and are dealing with conditions like Post-Traumatic Stress Disorder (PTSD), cognitive difficulties, or brain injuries. Sponsored by the Special Operations Care-Fund, this study will test four different treatments: hormone replacement, magnetic brain stimulation, ibogaine, and 5-Meo-DMT. The goal is to see how well these treatments work and how safe they are by observing changes in PTSD symptoms and cognitive abilities after the treatments.

To participate in this study, you need to be at least 18 years old and a veteran supported by the SOC-F Program. However, certain medical conditions could exclude you from participating, such as severe mental health disorders like schizophrenia or bipolar disorder, serious heart issues, or other significant health problems. If you join the study, you'll receive one of the four treatments and be monitored closely to assess how it affects your mental health and thinking abilities. The study is not currently recruiting participants, but it hopes to help improve the lives of veterans facing these challenges.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • At least 18 years of age
• • Sponsored by SOC-F Program
• Exclusion Criteria:
• • Diagnosis of Schizophrenia, Bipolar I or II disorder for which patient has been hospitalized or medicated, Depersonalization and/or Derealization Disorder
• • Cerebellar dysfunction, Epilepsy, Psychosis or acute confusional state, Dementia
• • Prolonged corrected QT interval (QTc) Interval (450ms in males; 470ms in females)
• • History of heart failure or hypertrophic heart
• • Active blood clots (e.g., Pulmonary embolism, Deep vein thrombosis)
• • Major respiratory conditions (e.g., Emphysema, Cystic fibrosis)
• • Severe chronic gastrointestinal issues (e.g., bleeding ulcer, leaky gut syndrome)
• • Within 6 months of surgeries
• • Abnormal blood test results (e.g., potassium or magnesium outside normal range)
• • Impaired kidney or liver function
• • Refusal to taper off of selective serotonin reuptake inhibitor (SSRI) medication