Intravenous Versus Perineural Ondansetron for Laparoscopic Sleeve Gastrectomy

Launched by TANTA UNIVERSITY · Feb 1, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at two different ways to give a medication called ondansetron to help with pain and nausea in patients having laparoscopic sleeve gastrectomy, a type of weight-loss surgery. The study will compare ondansetron given through an IV (into a vein) versus ondansetron given near the nerves in the area of the surgery. Researchers want to find out if one method is better than the other for helping patients feel more comfortable after their operation.

To participate in this study, you need to be between 18 and 65 years old, have a higher body weight (with a specific measurement known as BMI), and be in moderately good health, as defined by a standard used in anesthesia. If you have certain health issues, like allergies to the study drugs or a history of serious side effects from anesthesia, you would not be eligible. If you join the study, you can expect to receive one of the two types of ondansetron and will be monitored for how well it helps with pain and nausea after your surgery. This trial is currently recruiting participants, and it offers an opportunity to contribute to research that could improve recovery experiences for future patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients of either sex
• • American Society Anesthesiologists physical (ASA) status II-III
• • age between 18-65 years old
• • Body mass index (BMI) \>35 kg/m2 with comorbidity or \> 40 kg/m2 -- undergoing laparoscopic sleeve gastrectomy with intraoperative surgeon performed laparoscopic paragastric autonomic neural blockade..
• Exclusion Criteria:
• • Allergy to experimental drugs.
• • Known to have long QT, previous history of postoperative nausea and vomiting
• • Abuse of alcohol, analgesia, or sedative antidepressant drugs
• • Chronic pain disorders
• • History of previous upper gastrointestinal system surgery, those with surgery-related complications during or after surgery.
• • Liver or kidney failure
• • Performance of concomitant procedures in addition to laparoscopic sleeve gastrectomy
• • Anesthetic complications that may alter the postoperative management protocol.