The Efficacy of Dexamethasone in Combination With N-acetylcysteine in Preventing Neurocognitive Sequelae Due to Carbon Monoxide Poisoning

Launched by CHINA MEDICAL UNIVERSITY HOSPITAL · Feb 5, 2025

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ClinConnect Summary

This clinical trial is studying whether a combination of two medications, Dexamethasone and N-acetylcysteine, can help prevent delayed neurocognitive issues that sometimes occur after carbon monoxide poisoning. Carbon monoxide poisoning can lead to serious health problems, and while a treatment called hyperbaric oxygen therapy is often used, it's not always effective in preventing these long-term issues. Researchers believe that using Dexamethasone, which helps reduce inflammation, and N-acetylcysteine, an antioxidant that protects cells, together may better prevent these problems.

To participate in this study, individuals should have symptoms consistent with carbon monoxide poisoning and specific blood test results indicating elevated carbon monoxide levels. The trial is open to adults aged 65 and older, regardless of gender. Participants will be divided into two groups: one receiving the combination treatment and the other receiving standard care. Throughout the trial, the researchers will monitor participants for six weeks to see if the combination treatment successfully reduces the occurrence of delayed neurocognitive issues. If you or a loved one is interested in joining this study, please consider discussing it with your healthcare provider.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • History and clinical symptoms consistent with CO poisoning (initial blood carboxyhemoglobin (COHb) levels \>5%, or \>10% for smokers).
• Exclusion Criteria:
• • Concurrent use of other potentially lethal toxins. Severe trauma or burns that could be fatal. No spontaneous heartbeat or blood pressure before arrival. Poisoning time exceeding 24 hours before hospital arrival. Minors (under 18 years of age). Pregnant women. Patients or their families refuse to sign the consent form. Contraindications for the use of Dexamethasone or N-acetylcysteine (such as severe allergies) or when the physician assesses the risks outweigh the benefits.