Residual Gastric Content and GLP-1

Launched by UNIVERSITY OF ARKANSAS · Feb 3, 2025

Keywords

ClinConnect Summary

This clinical trial is looking into how well the stomach empties in patients who are taking a medication called GLP-1 before they undergo elective surgery. Even though patients are usually asked to fast before surgery, those on GLP-1 may still have food left in their stomachs, which can increase the risk of complications during anesthesia, particularly a condition known as aspiration. The study aims to find out how common this issue is by examining how full patients’ stomachs are after different fasting periods.

To participate in this trial, individuals must be at least 18 years old and in good health, classified as ASA physical status I to III, meaning they have minor to moderate health issues. However, people who are pregnant, have certain gastrointestinal problems, or are on specific medications that affect stomach emptying will not be eligible. If you join the trial, you can expect to provide information about your health and participate in tests to evaluate your stomach's condition. This study could help improve safety for future patients undergoing surgery while on GLP-1 medication.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥ 18 yr. ASA physical status I- III Elective surgery
• Exclusion Criteria:
• • Pregnancy
• • History of upper gastrointestinal disease or previous surgery on the esophagus, stomach or upper abdomen;
• • Documented abnormalities of the upper gastrointestinal tract such as gastric tumors; recent upper gastrointestinal bleeding (within the preceding 1 month).
• • Medicines that may delay gastric emptying (e.g., anticholinergic agents, opioid)
• • ASA class IV or above
• • Unable to understand English
• • Cardiac cases with low ejection fraction
• • Elderly patients above 65 years of age
• • Liver or renal transplant cases
• • Type 1 diabetes Patients on insulin or sulphonylurea medication