Project neuroARTEMIS

Launched by WAKE FOREST UNIVERSITY HEALTH SCIENCES · Feb 3, 2025

Keywords

ClinConnect Summary

The Project neuroARTEMIS clinical trial is researching how chronic stress impacts the brain and immune system, particularly in people living with HIV who also use stimulants. The goal is to understand how these factors influence feelings, thoughts, and behaviors, which could lead to better treatments for issues like depression and substance use. This study is looking for individuals aged 18 to 59 who have a confirmed HIV diagnosis, are currently taking HIV medications, and report using stimulants regularly.

If you participate in this trial, you will be involved in an intervention aimed at improving your mood and reducing stimulant use. The study is not yet recruiting participants, but once it starts, it will provide a supportive environment to explore these important issues. It’s essential to note that individuals with certain medical conditions, like serious brain infections or those on specific medications, may not be eligible to join.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 18-59 years old
• • Weekly use of stimulants reported in the past month or a score of 4 or more on the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST)
• • Confirmed HIV diagnosis
• • Current receipt of daily oral antiretroviral therapy (ART) medication
• • English fluency/literacy
• Exclusion Criteria:
• • Acute brain infection (e.g., neurosyphilis, toxoplasmosis)
• • Acutely symptomatic bipolar I or psychotic disorder
• • Prescription for immunomodulatory medications or other immunotherapy
• • Any MRI contraindications
• • If applicable, on antidepressant medication regimen for at least 2 months