Intraoperatively Observed Site of Origin and Growth Pattern of Medulloblastoma

Launched by CHRISTIAN DORFER · Feb 2, 2025

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Eligibility criteria

• Inclusion Criteria:
• • Patients who are referred for surgical resection of a medulloblastoma at a hospital with expertise in pediatric neurooncology
• • Both pediatric patients (aged \< 18 years at the time of diagnosis) and adult patients (aged \> 18 years at the time of diagnosis)
• Exclusion Criteria:
• • Patients who are preoperatively admitted with severe tumor hemorrhage accompanied by clinical deterioration are excluded because these patients frequently do not receive magnetic resonance imaging as would be necessary for the present study, and the intraoperative assessment of the STO is limited in accuracy due to decreased visibility caused by the intra- and extratumoral hemorrhage.
• • If an intraoperative complication occurs (e.g. bleeding) which impairs visibility of the neuroanatomic structures and does not allow an accurate assessment of the STO, the patient is excluded.
• • If the histopathological and molecular analysis does not confirm the diagnosis of a MB, the patient has to be excluded as well.