Acquisition of Cardiac Function Parameters in MRI and Echocardiography in Patients with Ethyltoxic Liver Cirrhosis and Transjugular Intrahepatic Portosystemic Shunt (TIPSS) Placement

Launched by STEPHANIE GRÄGER · Feb 4, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how heart function changes in patients with liver cirrhosis after they receive a specific procedure called a transjugular intrahepatic portosystemic shunt (TIPSS). The goal is to understand how often heart problems develop in the year following this treatment and to identify any changes in lab tests, clinical symptoms, or imaging results that may be related to these heart issues. Participants will undergo a series of heart scans, including cardiac magnetic resonance imaging (MRI) and echocardiograms, as well as blood tests at different times around their TIPSS procedure.

To participate in this study, individuals must be between 18 and 85 years old and have been diagnosed with decompensated liver cirrhosis. They also need to give their written consent to join. However, people who are pregnant, have certain medical implants that aren’t safe for MRI, or are in critical condition won’t be eligible. Participants can expect to have their heart monitored closely before and after the TIPSS procedure, which will help improve future care for patients with similar conditions.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age 18 to 99 years
• • Written informed consent of the patient
• • Decompensated liver cirrhosis, defined by clinical, imaging or laboratory criteria
• • Patient receives an elective TIPSS in the appropriate clinical context at the JUH
• Exclusion Criteria:
• • Pregnancy
• • Implants not suitable for magnetic resonance imaging
• • Medical/personal reasons against magnetic resonance imaging (claustrophobia, patient cannot lie flat or follow breathing commands)
• • Patient in critical condition or incompliant