Impact of Varying Doses of Prucalopride on Improving Gut Function Recovery After Elective Colorectal Surgery

Launched by FUTURE UNIVERSITY IN EGYPT · Feb 7, 2025

Keywords

ClinConnect Summary

This clinical trial is investigating how different doses of a medication called prucalopride can help improve bowel function after elective colorectal surgery. After such surgeries, many patients experience a condition called postoperative ileus, which can cause uncomfortable symptoms like nausea, vomiting, and difficulty passing gas or stool. The trial aims to find out if a higher dose of prucalopride (4 mg) can speed up recovery and reduce the time spent in the hospital compared to standard doses and a placebo (a pill with no active medication).

To be eligible for this trial, participants need to be planning to have elective colorectal surgery, such as procedures to remove parts of the colon or rectum. However, people who are having emergency surgeries, certain types of extensive surgeries, or have specific health issues will not be included. If you or a family member are interested in joining, you can expect to receive different doses of prucalopride during your recovery, and the study will help researchers understand how effective this treatment is in helping patients bounce back after surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • undergoing elective colorectal surgery, including but not limited to colectomy, rectal resection, and sigmoid resection.
• Exclusion Criteria:
• • Emergency surgery
• • Total colectomy
• • Creation of a stoma
• • Pre-existing gastrointestinal disorders
• • Severe renal or hepatic impairment
• • Known hypersensitivity to prucalopride.