Study on Evaluating the Effectiveness of Statins in the Treatment of Moyamoya Disease

Launched by BEIJING TIANTAN HOSPITAL · Feb 4, 2025

Keywords

ClinConnect Summary

This clinical trial is exploring how effective statin medications are in treating moyamoya disease, a condition that affects blood flow to the brain. Researchers will use advanced MRI scans to see how well the treatment works. The study is currently looking for participants aged 18 and older who have been diagnosed with moyamoya disease and have not had severe complications that could affect the study results.

To participate, individuals must be able to provide consent and have a mild disability score (meaning they can carry out daily activities with little help). Participants can expect to receive either the statin treatment or standard care, along with regular imaging check-ups to monitor their progress. It’s important to note that some people may not be eligible, such as those with certain other medical conditions or those who are pregnant. This study aims to provide valuable insights into how statins may improve outcomes for patients with moyamoya disease.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. The imaging examination meets the diagnostic criteria for moyamoya disease;
• • 2. Sign the informed consent form;
• • 3. Age ≥18 years old;
• • 4. Baseline mRS score ≤2 points;
• • 5. The patient receives revascularization/conservative treatment;
• • 6. There is at least 1 imaging follow-up result.
• Exclusion Criteria:
• • 1. Patients with atherosclerosis, autoimmune diseases, meningitis, Down syndrome, cranial trauma, or those who have undergone radioactive head irradiation, as these conditions may lead to secondary cerebrovascular disease and contribute to the development of Moyamoya syndrome;
• • 2. Individuals under the age of 18;
• • 3. Participants who refuse to take part in this study;
• • 4. Pregnant patients;
• • 5. Those with concurrent intracranial aneurysms, cerebrovascular malformations, brain tumors, or hydrocephalus;
• • 6. A history of stroke occurring more than three months prior to the diagnosis of Moyamoya disease;
• • 7. Individuals with a history of coronary heart disease or previous cardiovascular and cerebrovascular surgical interventions, including cerebral revascularization, intracranial artery stent implantation, carotid artery stenting, endarterectomy, coronary artery bypass grafting, or coronary stent implantation;
• • 8. Allergies to contrast media;
• • 9. Patients with missing imaging data or whose image quality cannot be analyzed;
• • 10. Individuals who refuse or are unable to undergo imaging follow-up;
• • 11. Patients receiving other types of lipid-lowering drug treatments.