Comparison of Outcomes of Management of Bowel Obstruction Pilot Study

Launched by UNIVERSITY OF WASHINGTON · Feb 4, 2025

Keywords

ClinConnect Summary

Millions of Americans each year experience adhesion-related small bowel obstruction (aSBO), a condition associated with significant morbidity and prolonged hospitalization. Adhesions formed after previous abdominopelvic surgery can cause twisting of the bowel resulting in injury and a cascade of inflammation that results in progressive bowel wall edema with narrowing of the bowel lumen. This leads to or worsens the bowel obstruction. Reversing this inflammation has the potential to reduce the severity and impact of aSBO, hasten the return of bowel function and avoid an emergency operation t...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adults ≥18 years of age recruited from UWMC
• • Patients presenting to surgical services through the Emergency Department, diagnosis of SBO, consulted by surgeon, and an urgent or emergency operation is deemed not necessary by surgeon.
• • Diagnosis of aSBO is established by;
• • 1. CT findings consistent with diagnosis of SBO; and
• • 2. signs and symptoms consistent with SBO; and
• • 3. Adhesions are the likely cause of SBO (absence of incarcerated hernia, internal hernia, masses, fistula, stricture, volvulus, acute episode of inflammatory bowel disease (IBD) flare, etc.).
• • Ability to provide written or electronic informed consent in English and answer teach-back questions
• Exclusion Criteria:
• • Signs and symptoms of peritonitis with emergency operation planned
• • Planned urgent operation within the next 12 hours
• • Allergy to dexamethasone
• • Surgery within prior 6 weeks
• • Unable or unwilling to return or be contacted for and/or complete research surveys
• • Currently incarcerated in a detention facility or in police custody (patients wearing a monitoring device can be enrolled) at baseline/screening
• • Individuals with latent infections who have an increased risk of infection.