Misoprostol in Missed Abortion

Launched by ASSIUT UNIVERSITY · Feb 8, 2025

Keywords

ClinConnect Summary

This clinical trial is studying the effectiveness of two different methods to help women who have experienced a missed abortion during the second trimester. Specifically, it compares using a Foley's catheter combined with a medication called Misoprostol against using just the Foley's catheter alone. The goal is to find out which method works better for ending a pregnancy when the fetus has died in the womb.

To qualify for the study, participants need to be women aged between 18 and 40 who are in the mid-trimester of their pregnancy (between 18 to 24 weeks) and have a specific type of cervix condition. Women who have had one previous cesarean section or have never had one are eligible. However, those with certain medical issues, such as severe asthma, significant anemia, or other serious health conditions, as well as those with active infections, cannot participate. If eligible, participants will receive the assigned treatment and will be closely monitored to see how well it works and to ensure their safety throughout the process.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Women aged between 18 - 40 years of age with mid-trimester fetal death inutero.
• • Singleton pregnancies from 18-24 weeks.
• • women with unfavourable cervix (Bishop Score \< 5) at the time of recruitment.
• • Previous one CS and non-previous CS pregnant women.
• Exclusion Criteria:
• • • Previous 2 CS or more.
• • Medical contraindications for prostaglandin therapy (allergy to prostaglandins or severe asthma).
• • co-morbidities like severe anemia (Hb \< 7g/dl), hypertension, diabetes, or coagulopathy .
• • Women with excessive vaginal discharge or rupture of membrane.
• • Women having any complication in previous caesarean like endometritis, reopening, scar dehiscence etc.
• • Active genital infection e. g. active genital Herpes simplex infection.