Role of Medication in Making Urine Less Acidic As Part of Kidney Stone Prevention

Launched by UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER · Feb 4, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at how different forms of potassium citrate can help prevent kidney stones by making urine less acidic. Potassium citrate is a common medication used for this purpose, and it comes in several forms, including over-the-counter tablets and prescription slow-release tablets. The goal of the study is to find out which form works best and which one patients prefer.

To participate, you need to be an adult aged 18 or older who has either had kidney stones before or is at high risk for developing them again. Each participant will take one form of potassium citrate for a week and then take a break for a week before trying the next form. Over the six-week study, participants will collect urine samples for 24 hours and fill out surveys about how they felt taking the medication. It’s important to follow a specific diet recommended for kidney stone prevention during the study. This trial is not yet recruiting participants, but if you meet the criteria, it could provide valuable insights into kidney stone prevention treatments.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • adults, 18 years or older
• • recurrent stone formers or first-time stone formers at high risk for recurrence
• • have a baseline 24-hour urine within six months from study enrollment
• • have the ability to adhere to a directed diet
• Exclusion Criteria:
• • minors (age \<18 years)
• • mentally incapacitated and/or unable to provide consent
• • prisoners
• • pregnant or breastfeeding individuals
• • concurrent potassium citrate therapy
• • concurrent thiazide therapy
• • chronic kidney disease (eGFR \<60)
• • solitary kidney
• • unable to take any of the study medications due to a prior adverse reaction or other health-related reason (ex: severe renal impairment, hyperkalemia, or severe acidosis or alkalosis).