Effect of Dexamethasone on Post-spinal Hypotension

Launched by SHAHEED MOHTARMA BENAZIR BHUTTO INSTITUE OF TRAUMA · Feb 5, 2025

Keywords

ClinConnect Summary

This clinical trial is investigating whether a medication called dexamethasone can help prevent a drop in blood pressure that sometimes occurs after spinal anesthesia in older adults undergoing orthopedic surgeries, like hip or knee operations. Researchers want to find out if giving intravenous (IV) dexamethasone before the surgery can make a difference in preventing this condition compared to a placebo, which is a treatment that looks like the medication but has no active ingredients.

To participate in this trial, you must be an older adult scheduled for orthopedic surgery and generally healthy, with specific criteria about your medical history. For example, patients with certain heart conditions or those who have had serious injuries may not be eligible. If chosen for the trial, you will either receive the dexamethasone or the placebo before your surgery. The study is currently looking for participants, so if you think you might qualify and are interested, it could be a good opportunity to help advance medical knowledge in this area.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patient undergoing orthopedic surgery in spinal anesthesia. ASA ≤ 2.
• Exclusion Criteria:
• • Patients with history of cardiac arrhythmias. Patients with history of acute coronary syndrome. Patient with history of polytrauma. Patients with contraindication to SA (e.g., coagulopathy, thrombocytopenia, allergy to local anesthetic agent) and those on steroids or serotonin related medications (e.g., selective serotonin reuptake inhibitor) will be excluded.