Imaging Skeletal Muscle Mitochondrial OXPHOS Activity In Acute Lymphoblastic Leukemia Survivors

Launched by ST. JUDE CHILDREN'S RESEARCH HOSPITAL · Feb 4, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how muscle activity and strength are affected in survivors of Acute Lymphoblastic Leukemia (ALL), a type of blood cancer that mostly affects children. Researchers want to compare muscle function and some specific muscle cells between ALL survivors and healthy volunteers. They also hope to understand how muscle health relates to overall physical performance in these survivors.

To participate in this study, you need to be at least 18 years old and a survivor of childhood ALL or a healthy volunteer. One of the key requirements is that you must have low muscle mass, which means your muscle strength is lower than what is considered normal for your height. Participants will undergo some tests that involve lying still for a while, and they will be asked questions about their health. It’s important to note that certain health conditions or treatments may exclude you from participating. If you're curious about how this study might help improve understanding of muscle weakness in cancer survivors, or if you meet the eligibility criteria, consider reaching out for more information!

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Survivor- or Control-Participant is age 18 years old or older at time of consent and enrolled in SJLIFE.
• • Survivor- Participant is childhood ALL survivor
• • Survivor- or Control Participant has low muscle mass as defined by relative lean mass z-score of less than or equal to -1 SD (lean mass divided by height in meters squared).
• • Survivor- or Control-Participant is able and willing to give informed consent
• Exclusion Criteria:
• • Survivor-Participant has history of cranial radiation.
• • Survivor- or Control-Participant has implanted medical devices or metal that would interfere with MRI or MRS
• • Female Survivor- or Control-Participant is pregnant.
• • Survivor- or Control-Participant is taking anticoagulants (e.g. aspirin, apixaban, coumadin, edoxaban, rivaroxaban)
• • Survivor- or Control-Participant weighs more than 300 pounds.
• • Survivor- or Control-Participant is allergic to local anesthetic (i.e., lidocaine, bupivacaine).
• • Survivor- or Control-Participant cannot lie flat on his/her back for 90 minutes or longer
• • Survivor- or Control-Participant has a current history of peripheral motor neuropathy.