Safety and Efficacy of Remote Ischemic Preconditioning in Patients with Aneurysmal Subarachnoid Hemorrhage After Aneurysm Clipping

Launched by BEIJING TIANTAN HOSPITAL · Feb 10, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a treatment called Remote Ischemic Conditioning (RIC) for patients who have had a serious brain condition known as aneurysmal subarachnoid hemorrhage (aSAH). This condition happens when a weakened blood vessel in the brain bursts, causing bleeding. To help stop the bleeding, doctors often perform a surgery called craniotomy, where they clip the aneurysm. The trial aims to find out if RIC, which involves using a blood pressure cuff to temporarily restrict and restore blood flow to an arm or leg, can improve recovery and reduce complications for these patients.

To participate in this study, individuals need to be between 18 and 80 years old and must have been diagnosed with aSAH that has been confirmed by imaging tests. They should also have had the necessary surgery within 24 hours of their diagnosis. Participants will be monitored to see how RIC affects their recovery and brain function following surgery. The results of this trial could help decide if RIC should become a standard part of treatment for patients with this serious condition.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Imaging examination confirmed aneurysmal subarachnoid hemorrhage.
• • 2. Responsible aneurysms received craniotomy clipping within 24 hours.
• • 3. 18≤ age ≤80 years old.
• • 4. Informed consent of the participant or legally authorized representative
• Exclusion Criteria:
• • 1. Patients with other types of cerebral hemorrhage.
• • 2. Prior neurological impairment (mRS Score \>1) or mental illness may confuse neurological or functional assessment.
• • 3. Severe comorbidities with a life expectancy of less than 90 days.
• • 4. Refractory hypertension (systolic blood pressure 180\>mmHg or diastolic blood pressure 110\>mmHg).
• • 5. RIC contraindications: severe soft tissue injury of lower limbs.
• • 6. Simultaneously participate in another research program to study a different experimental therapy.
• • 7. Any condition that the investigator believes may increase the patient's risk.