The Canadian Lung Outcomes in Users of Vaping Devices Study

Launched by UNIVERSITY OF BRITISH COLUMBIA · Feb 5, 2025

Keywords

ClinConnect Summary

The Canadian Lung Outcomes in Users of Vaping Devices Study is a clinical trial that aims to understand how vaping affects lung health, particularly in adolescents and adults. As vaping becomes more common, especially among young people, it's important to learn about its long-term effects on the lungs. The researchers believe that current methods for checking lung health might not be enough for people who vape. They plan to use new tests that involve exercise, advanced imaging, and special breathing tests to better detect any lung damage caused by vaping.

To participate in this study, adolescents aged 12 to 18 must either not use cigarettes or only use e-cigarettes, while adults aged 19 and older can be in various categories of tobacco use, including exclusive e-cigarette or cigarette users. Participants will undergo different tests to assess their lung function and overall health related to vaping. It’s important to note that those with certain medical conditions or recent smoking histories may not be eligible. This study aims to provide valuable insights that can help Canadians who vape understand the potential risks to their lung health.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• Adolescent arm:
• • Aged ≥12 and \<19 years old
• • Either 1) use neither combustible cigarettes nor e-cigarettes or 2) use e-cigarettes exclusively
• Adult arm:
• • Aged ≥19 years old
• • Fall into one of the following categories: 1) use neither combustible cigarettes nor e-cigarettes; 2) use combustible cigarettes exclusively, never using e-cigarettes; 3) use e-cigarettes exclusively, never using combustible cigarettes; or 4) use both combustible cigarettes and e-cigarettes currently
• Exclusion Criteria:
• Adolescent arm:
• • Contraindication to pulmonary function testing and cardiopulmonary exercise testing
• • Have smoked combustible cannabis within the last month and/or have a combustible cannabis smoking history of \>1 joint-year
• • Have smoked combustible cigarettes within the last 6 months
• • Have a physician-diagnosed chronic lung disease (such as asthma, cystic fibrosis, or bronchopulmonary dysplasia)
• • Inability to provide written informed consent
• Adult arm:
• • Contraindication to pulmonary function testing and cardiopulmonary exercise testing
• • Have smoked combustible cannabis within the last month and/or have a combustible cannabis smoking history of \>1 joint-year
• • Currently undergoing treatment for lung cancer
• • Inability to provide written informed consent
• • No limitations will be placed on the type of e-liquids used by participants; e.g., e-cigarette users of nicotine, tetrahydrocannabinol, and cannabidiol will be all enrolled.