Isolated Versus Combined Cognitive and Motor High-tech Rehabilitation

Launched by UNIVERSITA DI VERONA · Feb 5, 2025

Keywords

ClinConnect Summary

This clinical trial is exploring how different types of high-tech rehabilitation can help people with multiple sclerosis (MS) who have difficulties with thinking and movement. The researchers want to see if focusing only on cognitive skills (like memory and problem-solving), only on motor skills (like walking), or combining both types of training can improve daily functioning for those with MS. They are also looking to find out which patients benefit the most from each type of treatment.

To participate in this study, you should be between the ages of 65 and 74 and have mild to severe cognitive difficulties, along with some walking challenges. You should not have had any recent relapses or steroid treatments and should be able to use computer programs for the rehabilitation activities. If you join the trial, you can expect to undergo various rehabilitation sessions designed to enhance your cognitive and motor abilities, and you’ll be closely monitored throughout the process. This trial is currently recruiting participants, so if you meet the criteria and are interested in contributing to this important research, it might be a good opportunity for you.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • presence of mild (one or two neuropsychological tests below the cut-off score, 5th percentile) or severe (more than two neuropsychological tests below the cut-off score, 5th percentile) cognitive impairment,
• • mild to moderate walking disability with Expanded Disability Status Scale (EDSS) between 3 and 6,
• • no relapse or associated steroid use in the past three months,
• • adequate visual and auditory capacity to operate computer software.
• Exclusion Criteria:
• • presence of other neurological disorders than MS,
• • major psychiatric disorders,
• • high levels of anxiety and/or depression (score\>20 for Depression scale and up to 14 for Anxiety scale on Italian adaptation of the Depression, Anxiety and Stress Scale (DASS-21),
• • substance abuse,
• • any type of rehabilitation intervention in the month prior to recruitment
• • pharmacological therapy not well defined and/or changed during the study
• • presence of paroxysmal vertigo
• • lower limb botulinum toxin injections within the previous 12 weeks