Premixed, Sequential and Manually Mixed Administration of Intrathecal Fentanyl and Bupivacaine in Cesarean Section

Launched by TANTA UNIVERSITY · Feb 6, 2025

Keywords

ClinConnect Summary

This clinical trial is studying three different methods of giving pain relief during cesarean sections using two medications: fentanyl and bupivacaine. The goal is to find out which method—premixed, sequential, or manually mixed—works best for managing pain during and after surgery. If you are a woman between the ages of 18 and 40, have a healthy weight, and are scheduled for a cesarean section under spinal anesthesia, you may be eligible to participate.

Participants in this trial will receive one of the three methods of medication delivery as part of their routine care during the surgery. Your safety is a top priority, so there are certain conditions that would prevent someone from joining, such as having low blood pressure before surgery or certain medical conditions like preeclampsia (a pregnancy complication). If you are interested in learning more about your eligibility and what to expect, the study team will be happy to provide more details.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Age from 18 to 40 years.
• • Height between 150 to175 cm.
• • Body mass index (BMI) between 18.5 and 30 kg/m2.
• • American Society of Anesthesiology (ASA) physical status II.
• • Scheduled for cesarean section under spinal anesthesia.
• Exclusion Criteria:
• • Pre-operation hypotension and bradycardia.
• • Preeclampsia.
• • Multiple pregnancy and macrosomia.
• • Complete or partial failed spinal.
• • Patients with skin infections at the site of injection.
• • Patients with coagulation disorders.
• • Patients with spinal deformities.
• • Patients having regional nerve block other than spinal anesthesia.