A Comparison of Neuromuscular Recruitment in Trained and Untrained Adults

Launched by MAYO CLINIC · Feb 5, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how the nervous system controls muscle activity in older adults, specifically those aged 60 to 85. The researchers want to compare how well the nervous system works in people who regularly exercise (at least 5 days a week for 30 minutes) versus those who do not exercise regularly. The goal is to better understand how exercise affects muscle function and control in healthy adults who may be at risk for insulin resistance, a condition that can lead to diabetes.

To be eligible for the study, participants must be between the ages of 60 and 85, have a body mass index (BMI) between 18.5 and 38, and be able to understand English. They also need to be generally healthy and not have certain medical conditions or a history of specific surgeries. Participants will be asked to engage in neurological testing, which will involve measuring how their nervous system activates their muscles. This study is currently recruiting participants, and those who qualify will have the opportunity to contribute to important research that could help improve our understanding of healthy aging and exercise.

Gender

ALL

Eligibility criteria

• • Inclusion Criteria
• • Participant must have a BMI between 18.5 and 38
• • Participant be aged between 60 and 85
• • Regularly exercises at least 5 days a week a minimum of 30 minutes per day.
• • Engages in less than 2 days of exercise less than 30 minutes each day.
• • Participant must use the Mayo Clinic patient online portal.
• • Participant must be able to understand English without the need of an interpreter.
• • Must be willing to be contacted for research
• • Participant must be willing and capable to provide consent.
• • Participants shall be generally healthy as deemed acceptable by the principal investigator
• • Men and women will be participant in this study. Women cannot be pregnant during this study.
• Exclusion Criteria:
• • Surgical History - Gastric surgery, pacemaker placement, weight loss surgery, metabolic and obstetric surgery.
• • Smokers will be excluded from the study.
• • Medications: Insulins, common diabetic drugs, anti-hyperglycemic drugs, beta blockers cardiac selective, beta-blockers noncardiac selective, oral steroids, opioids anti-depressants, and hormones
• • Conidiations and Diagnosis: Disorder of coronary artery, hepatic failure, gastroparesis, disorder of the adrenal gland, drug related disorders, substance abuse, malignant neoplastic disease, psychotic disorders, disorder of skeletal muscle, finding of brain, chronic kidney disease, renal failure syndrome, disorder of pulmonary circulation, cerebrovascular disease, neuro developmental disorder, disorder of immune function, disorder of central nervous system.
• • Participants are not to have an abnormal value as part of a lipid panel within the past 6 months.
• • Participant will be excluded if they have recreational drug use or a history of alcohol abuse
• • Inability or unwillingness of individual or legal guardian/representative to give written informed consent.
• • Current or past participation within a specified timeframe in another clinical trial, as warranted by the administration of this intervention.
• • Participant will be excluded if they have epilepsy.
• • Participant will be excluded if they have cranial metal/device implants
• • Participant will be excluded if they are pregnant