CRIC Combined With MFT for Cardiovascular Adverse Events in Patients With Incomplete Revascularization of CAD

Launched by HENAN INSTITUTE OF CARDIOVASCULAR EPIDEMIOLOGY · Feb 6, 2025

Keywords

ClinConnect Summary

This clinical trial is exploring whether a combination of two therapies—chronic remote ischemic conditioning and mindfulness therapy—can help reduce heart-related problems in patients with coronary artery disease (CAD) who have not had complete revascularization. This means that for some patients, their heart arteries are still blocked, which can lead to chest pain and other symptoms. The goal of the study is to see if these therapies can improve their heart health and reduce the risk of serious events like heart attacks.

To participate in this trial, individuals must be at least 18 years old and diagnosed with coronary artery disease, specifically those who have significant blockages in their heart arteries and experience symptoms like chest pain or shortness of breath. However, certain conditions may exclude someone from participating, such as severe heart failure, uncontrolled high blood pressure, or other serious health issues. If eligible, participants will receive the therapies and be monitored over time to see how they respond. This trial is not yet recruiting, but it aims to offer potential new treatment options for those living with incomplete revascularization of CAD.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1) Age ≥18 years old
• • 2) Consistent with the diagnosis of coronary heart disease, complete revascularization was not performed (coronary angiography showed that at least one vessel with a reference diameter of 3.0mm had stenosis greater than 90%, and quantitative flow ratio (QFR) \< 0.80)
• • 3) Symptoms of myocardial ischemia (resting or exertional angina; Angina allele: chest tightness, shortness of breath, etc.);
• Exclusion Criteria:
• • Age \< 18 years old
• • Heart failure patients with NYHA class IV, or left ventricular ejection fraction (LVEF) \< 30%
• • Creatinine clearance \<15 mL/min (or eGFR \< 15 mL/min/1.73m²), or requires dialysis
• • Myocardial diseases such as hypertrophic cardiomyopathy, dilated cardiomyopathy, etc.
• • Uncontrolled or recurrent arrhythmic events (e.g., ventricular fibrillation, recurrent or symptomatic sustained ventricular tachycardia, complete heart block, atrial fibrillation with rapid ventricular rates, supraventricular tachycardia refractory to drugs)
• • Poorly controlled hypertension (SBP \> 180 mm Hg or DBP \> 110 mm Hg)
• • Active liver disease or persistent ALT or AST elevation ≥ 3 times the upper limit of normal
• • Unexplained CK \> 5 times the upper limit of normal, or elevated CK due to known muscle disease
• • Planned or anticipated cardiac surgery or revascularization before randomization
• • History of active malignancy (surgery, radiation therapy, and/or systemic therapy within the past 3 years)
• • Diagnosed or suspected upper extremity vascular malformations, aneurysms, arteriovenous fistulas, or thrombosis
• • Hearing impairment, unable to undergo mindfulness therapy
• • Currently participating in another drug or device study, or within 30 days of completing another drug or device study or receiving another investigational drug
• • Any life-threatening comorbid conditions expected to result in death within the next year (excluding cardiovascular diseases)
• • Alcoholism, substance abuse history; and unwilling or unable to stop alcohol or substance abuse during the study
• • History of major organ transplant (e.g., lung, liver, heart, bone marrow, kidney)
• • Investigator's judgment of known major active and uncontrolled disease, or any medical, physical, or surgical conditions (e.g., infection, significant blood, kidney, metabolic, gastrointestinal, or endocrine dysfunction) that may interfere with participation in the clinical study
• • As known to the investigator, the subject is unlikely to complete follow-up for more than 1 year or is expected to be unable to comply with the study requirements or understand the study's objectives and potential risks.