Anti-hypertensive Therapy and Exercise Treatment to Improve Vascular Health in Patients With Hypertension.

Launched by HEINRICH-HEINE UNIVERSITY, DUESSELDORF · Feb 7, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at how different treatments can help improve blood pressure and blood vessel health in people with high blood pressure, known as hypertension. The researchers want to compare the effects of taking blood pressure-lowering medications and doing personalized exercise training. They will also study how these treatments affect the body's metabolism and how blood vessels react, which can give us clues about improving vascular health.

If you're between the ages of 65 and 74 and have mild to moderate high blood pressure (with readings between 140 and 180 mmHg) but are not currently taking any medication for it, you may be eligible to participate. During the trial, you can expect to receive either medication, exercise training, or a combination of both, and you'll be supported by healthcare professionals throughout the process. It's important to know that those with certain medical conditions, like specific eye diseases or serious heart problems, may not be able to take part. Overall, this study aims to find better ways to manage high blood pressure and improve overall health in older adults.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • - systolic hypertension grade I-II (BP values \>140 mmHg to \<180 mmHg) without anti-hypertensive medication treatment
• Exclusion Criteria:
• • no written informed consent
• • age \<18 years
• • isolated diastolic hypertension
• • medical contraindications for the exercise treatment (for example orthopedic problems or an abnormal ECG during the cardio respiratory exercise test)
• • chronic eye diseases on both eyes (for example macular degeneration or glaucoma) or high intraocular pressure (\>20 mmHg)