Chronic Remote Ischemic Conditioning in Small Infarctions Associated with Stent-assisted Coiling of Unruptured Intracranial Aneurysms

Launched by THE FIRST AFFILIATED HOSPITAL WITH NANJING MEDICAL UNIVERSITY · Feb 10, 2025

Keywords

ClinConnect Summary

This clinical trial is investigating a treatment called Remote Ischemic Conditioning (RIC) to see if it can help reduce small brain injuries that sometimes happen during a procedure called stent-assisted coiling for unruptured brain aneurysms. These small injuries, known as microembolic infarctions, can occur during the procedure and may lead to tissue damage, even if patients don't notice any symptoms. The trial aims to find out if performing RIC before and after the procedure can lower the chances of these injuries happening and improve patient outcomes.

To participate in this study, individuals must be between 18 and 80 years old and have an unruptured brain aneurysm that requires treatment. They should be willing to receive the RIC therapy. However, certain conditions, such as severe heart issues or other specific health concerns, would exclude a person from joining the trial. Participants can expect to undergo the standard procedure while also receiving the RIC treatment, and the study will monitor them for any microembolic infarctions in the days and weeks following the procedure. This research is important as it could lead to improved safety and effectiveness in treating aneurysms.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1) Age 18-80; 2) Unruptured aneurysm with surgical indications; 3) Stent assisted aneurysm embolization; 4) Patients were willing to receive ischemic adaptation therapy.
• Exclusion Criteria:
• • 1) Age \< 18 years old; 2) Complicated with cerebrovascular malformations, moyamoya disease and other hemorrhagic cerebrovascular diseases or history; 3) pregnancy; 4) History of acute myocardial infarction within 1 month; 5) Peripheral vascular disease or peripheral neuropathy of the upper limb; 6) Upper limb vascular and soft tissue injury, or combined with limb deformity; 7) Severe subclavian artery stenosis or occlusion; 8) Poor blood pressure control, upper extremity basal systolic pressure ≥200mmHg; 9) Chronic kidney disease.