Immune Cell Populations in the Endometrium

Launched by JAGIELLONIAN UNIVERSITY · Feb 8, 2025

Keywords

ClinConnect Summary

This clinical trial is studying the role of immune cells in the uterus and how they may affect women's ability to become pregnant and maintain a pregnancy. Researchers want to understand how changes in immune cell populations, particularly natural killer (NK) cells, relate to infertility and recurrent miscarriages in women who haven't been able to find a clear reason for their difficulties. By comparing the immune cells in the blood and uterus of women with these challenges to those in women who have successfully conceived, the study aims to gain insights that could lead to better treatments or diagnostic methods.

To be eligible for this trial, participants must be women aged 18 to 45 who have experienced unexplained infertility and at least two miscarriages. Women who have had a miscarriage, surgery, or certain infections in the last three months, or who have taken antibiotics recently, cannot participate. If you join the study, you can expect to undergo tests that will help researchers better understand the connection between immune cells and fertility issues. This research could provide important information for improving care for women facing similar challenges in the future.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • age 18-45 years
• • idiopathic infertility
• • at least 2 miscarriages
• • other benign gynecological conditions subjected to endometrial sampling
• Exclusion Criteria:
• • miscarriage within last 3 months
• • abdominal/uterine surgery within last 3 months
• • viral/bacterial infection within last 3 months
• • antibiotic therapy within last 3 months