Effect of Er,Cr:YSGG Sub-Ablative Laser Irradiation on Fissure Caries Prevention in Permanent Molars
Launched by ALEXANDRIA UNIVERSITY · Feb 12, 2025
Trial Information
Current as of July 22, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is investigating a new method to prevent tooth decay (caries) in children by using a special type of laser on the grooves of their back teeth, known as molars. The goal is to see if this laser treatment can help make these teeth more resistant to decay compared to the traditional method of applying fluoride varnish. The study will involve children aged 6 to 12 who have certain conditions in their teeth that make them eligible for the trial.
Participants will receive either the laser treatment or fluoride varnish on their molars, and the researchers will check the health of these teeth over a year to see which method works better. To be eligible, children must have fully erupted first permanent molars that are not severely decayed and must be in good overall health. Parents will need to provide consent and ensure that their child can follow the study’s procedures. This trial is currently recruiting participants, and it aims to discover if this laser treatment could become a routine way to help prevent cavities in children.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Participants of age 6-12 years old
- • Patients ranking definitely positive or positive on Frankl behavior rating scale
- • Having at least two bilateral fully erupted first permanent molars with untreated non-cavitated occlusal surfaces with deep grooves, the included teeth will have International Detection and Assessment System (ICDAS-II)/ severity scores 0, 1 or 2
- • Initial DIAGNOdent Score not exceeding value of 25 indicating only enamel involvement
- • Patients whom their parents are willing to comply with all study procedures and protocols and will be given an informed consent to participate
- Exclusion Criteria:
- • Patients with any known medical history of systemic diseases
- • Patients having first permanent molar with hypoplastic or hypocalcified enamel
- • Patients using medications that may affect the oral flora or salivary flow
- • Patients treated with in-office fluoride treatment within the last 3 months prior to being enrolled in the study.
- • Patients showing evidence of poor oral hygiene according to Silness and Löe plaque index
About Alexandria University
Alexandria University, a leading academic institution in Egypt, is dedicated to advancing medical research and improving healthcare outcomes through innovative clinical trials. With a strong emphasis on collaboration and interdisciplinary approaches, the university leverages its extensive resources and expertise to conduct rigorous studies that address pressing health challenges. By fostering partnerships with healthcare professionals, industry leaders, and regulatory bodies, Alexandria University aims to contribute to the global body of medical knowledge and enhance the quality of patient care through evidence-based findings.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Alexandria, , Egypt
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported