At-Home Cardiac Rehabilitation for Adolescents at Risk for Heart Failure
Launched by CHILDREN'S HOSPITAL LOS ANGELES · Feb 12, 2025
Trial Information
Current as of June 26, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is studying how an at-home rehabilitation program, called cardio-oncology rehabilitation (CORE), can help improve heart fitness and overall well-being in young people who have survived cancer. The researchers want to see if exercise and healthy eating can boost cardiovascular fitness and mental health in adolescents at risk for heart problems after cancer treatment. They will also look at how well participants stick to the program and what resources help them maintain a healthy lifestyle.
To participate, you need to be between 10 and 21 years old, have a history of specific cancer treatments, and be currently in remission. You should also be able to perform some exercise and have a smartphone that works with a Fitbit device. Throughout the study, participants will undergo heart health tests and complete surveys about their quality of life before starting the program and again after six months. This trial offers a chance for young cancer survivors to focus on their heart health and make lasting changes to improve their lives.
Gender
ALL
Eligibility criteria
- • INCLUSION CRITERIA
- • Patients aged of 10-21 years at enrollment
- • Parent/legal guardian available for consent (if applicable), and patient available for assent and consent
- • History of anthracycline exposure +/- radiation
- • Currently in remission, with at least 6 months off chemotherapy
- • Able to perform CPET
- • Baseline CPET with VO2 \<80% (at start of study, or CPET at CHLA after January 2020)
- • Smartphone compatible with Fitbit (own or parent/legal guardian's)
- • Ability to complete and send diary and Fitbit information on a weekly basis
- • Ability to participate in monthly virtual check-in visits
- • Baseline activity prior to intervention \<30min/day, 2x/week
- • EXCLUSION CRITERIA
- • Inability to obtain consent/assent
- • Unable to accurately perform quality of life survey independently
- • No other primary medical diagnosis (e.g., Down Syndrome, Wolff-Parkinson-White Syndrome, congenital heart disease) or history of cardiothoracic surgery
- • Contraindication to moderate activity (\>3 METs). Examples include history of malignant arrhythmias, exercise-induced syncope, severe symptoms of HF (NYHA IV, ACC/AHA Stage D)
- • Unable to perform CPET, echocardiogram, EKG, or obtain laboratory studies
- • Unable to perform mild activity for at least 0.5h/day and at least 2x/week
- • Unable to come to hospital for study visits at 0 and 6 months
- • Unable to complete study-related surveys
- • Unable to complete and send diary and Fitbit information on a weekly basis
- • Unable to check-in monthly on virtual platform
- • On beta blockade
- • Pregnancy
About Children's Hospital Los Angeles
Children's Hospital Los Angeles (CHLA) is a renowned pediatric healthcare institution dedicated to advancing the health and well-being of children through innovative research and clinical care. As a leading clinical trial sponsor, CHLA is committed to conducting high-quality, ethical research that addresses critical pediatric health issues. With a focus on translating scientific discoveries into effective treatments, CHLA collaborates with multidisciplinary teams and leverages state-of-the-art facilities to support a wide range of clinical trials. Their mission is to enhance the understanding and treatment of childhood diseases, ultimately improving outcomes for young patients and their families.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Los Angeles, California, United States
Patients applied
Trial Officials
Jennifer Su, MD
Principal Investigator
Children's Hospital Los Angeles
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported