Intravenous Methadone Versus Intrathecal Morphine for Analgesia Following Cesarean Delivery
Launched by MAYO CLINIC · Feb 10, 2025
Trial Information
Current as of July 24, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is studying the differences in pain management after a scheduled cesarean delivery by comparing two types of medication: intrathecal morphine and intravenous methadone. Specifically, it aims to see how much pain relief each medication provides and how much additional pain medication patients need in the first 48 hours after their surgery.
To participate in this study, women must be at least 18 years old, speak English, and have a scheduled cesarean delivery. However, certain health conditions may prevent eligibility, such as severe respiratory issues or a history of adverse reactions to opioid medications. Participants will receive either the morphine or methadone and will be monitored for their pain levels and medication needs following their surgery. This trial is currently recruiting participants, so if you or someone you know fits the criteria, it could be an opportunity to contribute to important research in pain management after childbirth.
Gender
FEMALE
Eligibility criteria
- Inclusion Criteria:
- • English-speaking
- • Age over 18 years old
- • Scheduled cesarean delivery
- Exclusion Criteria:
- • Any contraindication to the administration of a spinal technique for anesthesia
- • History of intolerance or adverse reaction to opioid medications
- • History of chronic pain, opioid use \>30 OME/day, or substance use disorder
- • History of obstructive sleep apnea, chronic obstructive pulmonary disease, or respiratory compromise (SpO2 \<92% on room air, or has a pre-existing oxygen requirement)
- • History of liver or kidney failure
- • Diagnosis of pre-eclampsia with current pregnancy
- • Depression requiring more than one medication
- • Planned use of CSE technique
- • BMI \>50.0 kg/m2
- • ASA status IV, V
- • No prior history of an ECG demonstrating QTc \> 440ms
- • Surgical complication requiring conversion to general anesthesia
About Mayo Clinic
Mayo Clinic is a renowned nonprofit medical practice and research institution dedicated to providing comprehensive healthcare and advancing medical knowledge through innovative research and education. With a commitment to patient-centered care, Mayo Clinic conducts numerous clinical trials aimed at exploring new therapies and improving treatment outcomes across various disciplines. Leveraging a multidisciplinary approach, the institution collaborates with leading experts and cutting-edge technology to ensure rigorous scientific standards and ethical practices in all its research endeavors. Through its trials, Mayo Clinic seeks to translate breakthroughs in science into tangible benefits for patients, fostering advancements in medicine that enhance health and quality of life.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Rochester, Minnesota, United States
Patients applied
Trial Officials
Emily E Sharpe, M.D.
Principal Investigator
Mayo Clinic
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported