Daily Aspirin vs Split Dosing in High-risk Pregnancies (DASH)

Launched by THOMAS JEFFERSON UNIVERSITY · Feb 12, 2025

Keywords

ClinConnect Summary

The DASH trial is studying how different ways of taking aspirin might help pregnant women at high risk for complications like preeclampsia and preterm birth. Preeclampsia is a serious condition that can affect both the mother and baby, and aspirin is often recommended to lower these risks. In this study, women who are recommended to take aspirin will be divided into two groups: one group will take a higher dose of 162 mg once a day, while the other group will take a lower dose of 81 mg twice a day. Researchers want to see how these different doses affect how well aspirin works and whether they can improve outcomes for mothers and their babies.

To participate in this trial, women must be between 16 and 55 years old and in early pregnancy (less than 16 weeks). They should have at least one high-risk factor for preeclampsia or two moderate risk factors, based on guidelines from health experts. However, women with certain health issues, like a bleeding disorder or those taking other blood-thinning medications, cannot join the study. Participants will be monitored throughout the trial to understand how each dosing method impacts their health and pregnancy outcomes. This research aims to find the best way to use aspirin safely and effectively in pregnancy, ultimately helping to improve health for both mothers and their babies.

Gender

FEMALE

Eligibility criteria

• • Inclusion Criteria
• • Singleton gestation gestational age \<16 0/7 weeks, dating confirmed with ultrasound
• • ≥1 high risk factor for preeclampsia or ≥2 moderate risk factors as per United States Preventative Services Task Force (2021)
• • Recommendation for 162mg aspirin daily in pregnancy
• • Age 16-55 years old
• • Exclusion criteria
• • Contraindication to aspirin
• • Current or planned use of any other anticoagulation
• • Thrombocytopenia, other known platelet or bleeding disorder
• • Abnormally elevated baseline PFA-100 epinephrine closure time prior to aspirin initiation