Lifestyle Intervention Among Participants of the French Colorectal Cancer Screening Program (LIFE-SCREEN)

Launched by CENTRE LEON BERARD · Feb 10, 2025

Keywords

ClinConnect Summary

The LIFE-SCREEN trial is a research study designed to help people at higher risk for colorectal cancer learn about healthy lifestyle choices that may prevent the disease. The study will look at how effective guidance on diet and lifestyle—based on recommendations from cancer experts—can improve participants' adherence to these health tips, their overall quality of life, and their physical measurements like weight.

To participate, individuals must be between 12 and 27 years old, have a higher risk of colorectal cancer but currently be cancer-free, and be willing to commit to the study for a full year. They should also be able to read and understand French. Participants can expect to receive support and advice on making healthier lifestyle choices, which may lead to positive changes in their health. It's important to note that certain individuals, such as those with specific medical conditions or severe dietary restrictions, may not be eligible to join the trial.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Having read the information note and agreeing to participate
• • Will and availability to be committed for a full year
• • At high risk for CRC but CRC negative
• • Affiliated to a health security system
• • Having a score on the adherence to the recommendation lower than or equal to 7 out of 9 at baseline.
• • Able to read, write and understand French
• Exclusion Criteria:
• • Under a strict diet such as meal replacements, diets for co-morbidities such as diabetes
• • Immobile due to physical constraints (e.g. handicap that is not compatible with physical activities)
• • Extensive intestinal surgery such as colectomy or surgical resection of the colon
• • Chronic gastrointestinal illness (IBD, IBS, celiac disease)
• • Colorectal cancer confirmed or history of a primary cancer
• • Severe malnutrition
• • Pregnant
• • Participation in another lifestyle study
• • NB : For this study, there is no exclusion period from other research, and participants can simultaneously take part in another study unless it concerns lifestyle.