Initial Oral Antibiotics for Bone and Joint Infections in Children

Launched by RIGSHOSPITALET, DENMARK · Feb 13, 2025

Keywords

ClinConnect Summary

This clinical trial is studying the effectiveness and safety of starting treatment with oral antibiotics for children and teenagers who have uncomplicated bone and joint infections. Previous research has shown that oral antibiotics can work just as well as intravenous (IV) antibiotics, which are given through a vein, but we need to see how well oral antibiotics perform in real-world situations. The goal is to gather more information on how these medications can help young patients with bone and joint infections.

To be eligible for this study, children and adolescents aged 3 months to 17 years must have uncomplicated bone and joint infections and will be treated with initial oral antibiotics. Certain risk factors, like severe illness or rapid worsening of symptoms, will exclude some patients from participating. Those who join the trial can expect regular follow-ups to monitor their health and the effectiveness of the treatment. This study is currently recruiting participants, and it aims to improve understanding of how to best treat these infections in young patients.

Gender

ALL

Eligibility criteria

• • Children and adolescents aged 3 months to 17 years with uncomplicated bone and joint infections treated with initial oral antibiotics.
• According to Danish Nationwide Guidelines (initiated in 2024), initial oral antibiotics are recommended to patients with no risk factors for complicated disease. Risk factors include for complicated disease include:
• • 1. Severe illness or sepsis
• • 2. Rapid symptom progression
• • 3. Pronounced symptoms, including severe pain
• • 4. Pronounced soft tissue involvement
• • 5. Foreign material or post-surgical infection
• • 6. Infection with a resistent or rare pathogen, e.g., Salmonella or MRSA
• • 7. Severe comorbidity, including immunodeficiency
• • Patients who have received intravenous antibiotic therapy for less than 24 h before oral antibiotics will be included