A Study of Invikafusp Alfa (STAR0602), a Selective T Cell Receptor (TCR)-Targeting, Bifunctional Antibody-fusion Molecule, in Combination With Sacituzumab Govitecan in Participants With Advanced Solid Tumors

Launched by MARENGO THERAPEUTICS, INC. · Feb 10, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a new treatment called Invikafusp alfa, which is a special type of antibody designed to target certain cells in the body, in combination with another medication called Sacituzumab Govitecan. The goal is to see how safe and effective this combination is for patients with advanced solid tumors, specifically focusing on those with triple-negative breast cancer and certain types of hormone receptor-positive breast cancer that cannot be surgically removed.

To participate in this trial, individuals should have measurable cancer that has either progressed or come back after previous treatments. They should be between the ages of 65 to 74 and can be of any gender. Participants will need to have their tumors confirmed with imaging tests, and they should not have any serious infections or other major health issues that could interfere with the study. While in the trial, participants will receive the study medications and be closely monitored for any effects or changes in their condition. It's important to know that the trial is currently recruiting new participants, so those who meet the criteria may have the opportunity to join this study and contribute to important research in cancer treatment.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Have measurable disease as per RECIST v1.1 criteria and documented by CT and/or MRI. Cutaneous or subcutaneous lesions must be measurable by calipers.
• 2. Tumor Type:
• • mTNBC (Safety Run-in and Cohort A): Progression or recurrence of locally advanced or metastatic TNBC
• • HR+/HER2- mBC (Safety Run-in and Cohort B): Progression or recurrence of locally advanced or metastatic HR+/HER2- breast cancer
• 3. Symptomatic central nervous system (CNS) metastases must have been treated, be asymptomatic for ≥ 14 days, and meet the following at the time of enrollment:
• • No concurrent treatment for CNS disease (eg, surgery, radiation, corticosteroids \> 10 mg prednisone/day or equivalent); No concurrent leptomeningeal disease or cord compression.
• Exclusion Criteria:
• 1. History of known autoimmune disease with exceptions of:
• • Vitiligo
• • Psoriasis
• • Atopic dermatitis or other autoimmune skin condition not requiring systemic treatment
• • History of Graves' disease, now euthyroid for \> 4 weeks
• • Hypothyroidism managed by thyroid replacement
• • Alopecia
• • Arthritis managed without systemic therapy beyond oral nonsteroidal anti-inflammatory drugs
• • Adrenal insufficiency well-controlled on replacement therapy
• • 2. Major surgery or traumatic injury within 8 weeks before first dose of study intervention
• • 3. Unhealed wounds from surgery or injury
• • 4. Clinically significant cardiovascular/vascular disease, gastrointestinal disorders, inflammatory processes, pulmonary compromises
• • 5. Active viral, bacterial, or systemic fungal infection requiring parenteral treatment within 7 days prior to the initiation of study intervention.
• • 6. Vaccination with any live virus vaccine within 4 weeks prior to the initiation of study intervention administration. Inactivated annual influenza vaccination is allowed.
• • 7. Participants who are known to be human immunodeficiency virus positive or hepatitis B or C positive and have uncontrolled disease.
• • 8. Second primary invasive malignancy not in remission for ≥ 1 year. Exceptions include non-melanoma locally advanced skin cancer, cervical carcinoma in situ, localized prostate cancer (Gleason score ≤ 7), resected melanoma in situ, or any malignancy considered to be indolent and never required systemic therapy, with the exception of indolent lymphomas.
• • 9. Pregnant, likely to become pregnant, or lactating women (where pregnancy is defined as the state of a female after conception and until the termination of gestation)
• • 10. Treatment with \>10 mg per day of prednisone (or equivalent) or other immune-suppressive drugs within 7 days prior to the initiation of study intervention. Exceptions may be made for participants who have had allergic reactions to iodinated contrast media. Steroids for topical, ophthalmic, inhaled, or nasal administration are allowed