Clinical and Radiographic Evaluation of Allogenic Dentin Grafts for Alveolar Ridge Preservation

Launched by JORDAN UNIVERSITY HOSPITAL · Feb 9, 2025

Keywords

ClinConnect Summary

This clinical trial is investigating a new way to help preserve the alveolar ridge, which is the bony area in the jaw where teeth are anchored. After a tooth is extracted, it’s important to maintain this area for future dental work, like implants. The study will use allografts, which are grafts made from human teeth donated by healthy individuals, to see how well they work for this purpose. Researchers will compare two types of allografts: one that has had minerals removed and another that is whole, to determine their effectiveness and safety.

To be eligible for this trial, you should be between 18 and 60 years old and need at least three teeth extracted for dental reasons. It's important that you are in good health, without conditions that could affect healing, and willing to participate in follow-up visits. If you choose to participate, you'll receive one of the graft types and be monitored to help us understand how well it works in preserving the bone. This study could lead to improved dental treatments with fewer complications compared to traditional bone grafts.

Gender

ALL

Eligibility criteria

• Inclusion and Exclusion Criteria for Donors:
• Inclusion Criteria:
• • Students, interns, or residents willing to participate and provide informed consent.
• • No history of systemic diseases such as diabetes, hepatitis, or immune disorders.
• • Negative blood screening for HIV, HBV, and HCV.
• • Non-smokers or individuals who have not smoked within the last six months.
• Exclusion Criteria:
• • History of systemic conditions affecting oral or overall health.
• • Positive blood tests for communicable diseases.
• • Active oral infections or untreated dental caries.
• • Pregnant or lactating individuals.
• • Individuals with a history of smoking or substance abuse within the last six months.
• Inclusion and Exclusion Criteria for Recipients:
• Inclusion Criteria:
• • Patients aged 18-60 years, requiring extraction of at least three teeth for clinical or therapeutic reasons.
• • Patients in good systemic health without conditions that impair bone healing.
• • Willingness to provide informed consent and participate in follow-ups.
• Exclusion Criteria:
• • Systemic conditions such as diabetes, osteoporosis, or immunodeficiency that could impair bone regeneration.
• • Active oral infections at extraction sites.
• • History of radiation therapy to the head and neck region.
• • Smoking or smoking history within the last six months.
• • Use of medications affecting bone metabolism (e.g., bisphosphonates, steroids).
• * Pregnancy or lactation. Additional Justification for Extraction: Teeth chosen for extraction must meet one or more criteria:
• • Severe periodontal disease.
• • Irreversible pulpitis or structural damage.
• • Non-restorable condition impacting oral health or functionality.