Feasibility of a Remotely-Delivered Resistance Training Program for Cognitive Function in Men Living With and Beyond Prostate Cancer

Launched by UNIVERSITY OF TORONTO · Feb 10, 2025

Keywords

ClinConnect Summary

This clinical trial is looking into whether a remote resistance training program can help improve thinking and memory skills in men who are living with or have survived prostate cancer. Prostate cancer treatments, especially a type called androgen deprivation therapy (ADT), can lead to issues with cognitive function. The researchers want to see if an 8-week exercise program, delivered online, can make a difference for these men, especially since many face challenges like transportation or time that can make getting to a gym difficult.

To participate in this trial, men must be at least 18 years old and have had treatment for localized or certain types of prostate cancer, specifically those who have undergone ADT. They should also have mild cognitive impairment and be largely inactive, meaning they do not get much exercise. Participants will need to have a webcam and internet access to join the program remotely. If you qualify and join, you can expect to engage in guided resistance training exercises from the comfort of your home, helping you improve both your physical strength and cognitive health.

Gender

MALE

Eligibility criteria

• Inclusion Criteria:
• • ≥18 years of age
• • localized or asymptomatic metastatic primary prostate cancer (i.e., androgen receptor axis agents \[ARATs\] including conventional ADT, abiraterone, enzalutamide)
• • a history of ADT treatment
• • not currently undergoing radiation
• • no neurological or musculoskeletal co-morbidity inhibiting exercise
• • mild cognitive impairment as determined by the TICS-M \[scores between 21-24 to separate individuals with mild cognitive impairment and normal cognition (\>24)\]
• • not physically active (self-report \<90 minutes of MVPA/week and \<2 days of RT/week)
• • physician clearance to participate
• • access to a webcam and internet
• • able to complete the study in English.
• Exclusion Criteria:
• • a medical condition that prevents unsupervised exercise
• • presence of other primary or recurrent invasive cancer
• • have experienced a fall in the last 12 months
• • use a gait aid device
• • current participation in other exercise programs/trials
• • colour-blind since the objective cognitive tests require participants to distinguish between colours.