Perioperative Lidocaine Infusions for the Management of Pain From Burn Injury

Launched by UNIVERSITY OF WASHINGTON · Feb 10, 2025

Keywords

ClinConnect Summary

This clinical trial is studying whether IV lidocaine, a medication given through an intravenous (IV) line, can help manage pain for patients with burn injuries who are undergoing a specific surgical procedure called wound debridement. The researchers hope that using lidocaine will reduce the need for stronger pain medications called opioids, improve overall pain control, and lower the chances of complications that can arise from using opioids for a long time.

To participate in this study, individuals must be at least 18 years old with acute burn injuries affecting less than 20% of their body. Participants will be randomly assigned to receive either the lidocaine treatment or a saline solution (placebo) during their surgery, and this treatment will continue for 48 hours afterward. They will be asked about their pain levels at different times during this period and again two weeks after surgery. Importantly, neither the participants nor the medical staff will know which treatment they are receiving to ensure fair results. This trial is not yet recruiting participants, but it aims to find new ways to manage pain effectively and safely.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Acute burn patients
• • 18 years or older
• • \<20% Total Body Surface Area
• • Wound debridement surgery scheduled at Harborview Medical Center
• Exclusion Criteria:
• • History of polysubstance use
• • Chronic opioid use (MED\>40mg for more than 6 weeks)
• • Cases where the known clinical standard care would be to keep patient intubated postoperatively
• • Cases where the known clinical standard care would avoid IV Lidocaine infusion
• • Allergy to amide local anesthetics
• • Any elevated risk for local anesthetic systemic toxicity as determined by the study team
• • Cardiac arrythmias or cardiovascular instability (e.g. shock)
• • Severe renal or hepatic impairment
• • Pregnancy
• • Local anesthesia will be given by another route (e.g. nerve block)
• • Prisoners
• • Non-English Speaking/reading