Nasal Obstruction With Oxymetazoline and Corticosteroids

Launched by WASHINGTON UNIVERSITY SCHOOL OF MEDICINE · Feb 11, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a new treatment for people who have persistent nasal obstruction, which is a condition that makes it hard to breathe through the nose. The researchers want to see if using a combination of two medications—oxymetazoline, which is a nasal decongestant, and an intranasal corticosteroid (a type of nasal spray)—works better than just using the corticosteroid alone. This trial is particularly important for patients who have not found relief with standard treatments and are looking for an effective long-term solution.

To participate in the trial, individuals must be at least 18 years old, have experienced nasal obstruction, and have previously tried using topical steroids without success. Additionally, participants should not want surgery or may not be suitable candidates for it due to other health issues. Those interested will need to stop using other nasal sprays (except saline) and oral decongestants before joining the study. Participants can expect to be closely monitored for how well the treatment works and to ensure their safety throughout the trial.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. males and females ages 18 years or older
• • 2. have a history of nasal obstruction
• • 3. have failed a trial of topical steroids (that included at least 1 month of daily use)
• • 4. ability to read, write, and understand English
• • 5. either do not desire surgery or are poor surgical candidates due to medical comorbidities.
• • 6. Patients who have had prior use of oxymetazoline or other nasal decongestants are eligible for the study but must have stopped usage 4 weeks prior to randomization.
• • 1. Must be willing to stop using any other nasal sprays, besides saline, and oral decongestants.
• Exclusion Criteria:
• • 1. Any history of sinonasal mass/tumor
• • 2. Any history of nasal polyps
• • 3. a known history of chronic sinusitis
• • 4. an allergy to oxymetazoline
• • 5. or who have any medical contraindication to oxymetazoline use, such as pulmonary hypertension.