The ROAR Study: Reactive Oxygen Species and Reproduction

Launched by UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · Feb 13, 2025

Keywords

ClinConnect Summary

The ROAR Study is looking into how oxidative stress, which is an imbalance between free radicals and antioxidants in the body, affects fertility, particularly in women undergoing in vitro fertilization (IVF). The study aims to understand how levels of oxidative stress in both women and their male partners relate to the quality of eggs and embryos. By measuring these levels in the fluid surrounding the eggs and in blood samples, the researchers hope to see how they impact the chances of a successful pregnancy through IVF.

To participate in this study, women must be between the ages of 18 and 43 and planning to undergo a specific type of IVF called blastocyst culture for genetic testing. Their male partners should also be at least 18 years old. It's important to note that women over 43 or those planning different types of IVF procedures will not be eligible. Participants can expect to provide samples and undergo assessments related to their fertility, helping researchers gain valuable insights that could improve IVF outcomes for couples facing infertility challenges.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Female age 18-43 years
• • 2. Subjects planning blastocyst culture for preimplantation genetic screening (PGS) for aneuploidy.
• • 3. Male partners 18 years of age or older.
• Exclusion Criteria:
• • Female partner age 44 or older
• • Planning fresh transfer (hybrid PGS cycle)
• • Cleavage stage biopsy