Proton Versus Photon Radiotherapy in Adults With Primary Brain Tumors

Launched by TATA MEMORIAL CENTRE · Feb 12, 2025

Keywords

ClinConnect Summary

This clinical trial is investigating two types of radiation therapy—proton beam therapy and conventional photon therapy—for adults with specific types of brain tumors, such as meningiomas and gliomas. Proton therapy is a newer method that aims to deliver radiation more precisely, potentially reducing the amount of radiation exposure to healthy parts of the brain. This is important because traditional radiation can lead to side effects like memory problems, hormonal changes, and other neurological issues. The study will involve 156 patients who will be randomly assigned to receive either proton or photon therapy to see if proton therapy can help them live longer and healthier lives without complications from the treatment.

To be eligible for this trial, participants must be between 18 and 70 years old, have a primary brain tumor that is expected to have a good prognosis (meaning they are likely to survive for more than five years), and require targeted radiation therapy. They should also be able to perform daily activities with some assistance. However, those who have had previous radiation, have multiple tumors, or need different types of radiation therapy will not be included. If someone qualifies and chooses to participate, they will receive either type of radiation therapy as part of the study, and their health will be monitored to assess the effectiveness and safety of the treatment.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Primary brain tumors
• • Age at irradiation: 18 to 70 years
• • Karnofsky Performance Status ≥ 60
• • Diagnosis (histopathological/ radiological) of primary brain tumor with an expected survival of \>5 years (e.g., grade 2-3 diffuse glioma, low-grade glial/ glioneuronal tumors, ependymoma, meningioma, pituitary tumors, schwannoma, craniopharyngioma, etc.)
• • Planned for focal cranial radiotherapy
• • Informed consent taken
• Exclusion Criteria:
• • Re-irradiation
• • Palliative radiotherapy
• • Multifocal or multicentric disease
• • Planned for whole brain irradiation or craniospinal irradiation
• • Planned for hypo-fractionated or stereotactic radiotherapy