Resource Intervention to Support Equity (RISE) in High-Risk Neuroblastoma

Launched by DANA-FARBER CANCER INSTITUTE · Feb 13, 2025

Keywords

ClinConnect Summary

The Resource Intervention to Support Equity (RISE) trial is studying whether adding a new support program, called Pediatric RISE, to the usual care can help children with high-risk neuroblastoma and their families. This study focuses on families who are facing financial difficulties, specifically those with low incomes. The goal is to see if this extra support can improve the well-being of both the child and their parents during treatment.

To participate in this trial, children between the ages of 0 and 17 who have recently been diagnosed with high-risk neuroblastoma and are receiving treatment at specific hospitals may be eligible. Families must report a low income, defined as earning less than twice the federal poverty level. Participants will be randomly assigned to receive either the usual supportive care alone or the usual care plus the Pediatric RISE program for six months. The trial is not yet recruiting participants, but it aims to help families by providing additional resources during a challenging time.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patient cohort: The randomized Phase II multi-center RISE intervention will be conducted among a population of poverty-exposed children with high-risk neuroblastoma. Poverty will be a priori defined as parent-reported low-income (\<200% Federal Poverty Level). Children receiving treatment for cancer at study sites will serve as the study cohort, with parents/guardians as survey informants and intervention recipients on behalf of their minor children given that parents (not children) typically manage household finances.
• • Patient newly diagnosed with high-risk neuroblastoma
• • Patient has established care at study site and initiated cancer-directed therapy
• • Patient has not yet initiated Induction Cycle 3
• • Patient aged 0-17 years at the time of consent
• • Parent/guardian screened positive for self-reported low-income (\<200% Federal Poverty) \*
• • Family primary residence in MA, PA, IL, CA, WA, CT, GA, WI and OH
• • Both patients co-enrolled on ANBL2131 or those receiving standard of care therapy at their center are eligible to participate
• • Patients of all languages are eligible to participate
• Exclusion Criteria:
• • Foreign national family receiving care as an Embassy-pay patient.
• • Child or household member receiving SSI