Nicotine Patch Plus Nicotine Mouth Spray Versus Nicotine Reduction for Vaping Cessation

Launched by UNIVERSITY OF AUCKLAND, NEW ZEALAND · Feb 11, 2025

Keywords

ClinConnect Summary

This clinical trial is studying the best ways to help people quit vaping. Researchers in New Zealand want to find out if using a combination of a nicotine patch and a nicotine mouth spray (called nicotine replacement therapy or NRT) is more effective than gradually reducing the amount of nicotine in a vape. Both methods will be paired with written support to help participants stay motivated and succeed in quitting. The goal is to see if the combination therapy can help more people stop vaping for good.

To take part in this study, you need to be at least 16 years old, live in New Zealand, and vape nicotine weekly. You should also be motivated to quit vaping in the next two months and be able to provide consent. Participants will receive support materials and will be monitored throughout the trial. It’s important to note that if you are currently using tobacco, have had serious heart problems recently, or are part of another vaping cessation program, you won’t be eligible to join. This trial is a great opportunity for those ready to make a change and find effective support in their journey to quit vaping.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Live in New Zealand.
• • Vape nicotine at least weekly (one or more days out of the past seven days).
• • Used to smoke (i.e. they have smoked tobacco regularly but not at all in the past six months) or have never smoked (i.e., they have never been a regular user of smoked tobacco, defined as less than 100 cigarettes in their lifetime).
• • Are aged ≥16 years.
• • Are motivated to quit vaping in the next eight weeks.
• • Are able to provide consent.
• • Have access to the internet via a computer or smart phone.
• • Are a registered patient at a New Zealand medical facility.
• Exclusion Criteria:
• • They have another person in their household currently enrolled in the study.
• • They smoke tobacco currently or were a recent regular user of tobacco.
• • They are enrolled in another vaping cessation programme/trial.
• • They self-report having had a serious cardiovascular event, or hospitalisation for a cardiovascular complaint, in the previous four weeks (e.g. stroke, myocardial infarction, unstable angina, cardiac arrhythmia, coronary artery bypass graft and angioplasty).
• • They self-report uncontrolled hypertension.
• • They have a strong preference to use/not use NRT or nicotine tapering.
• • They are current users of smoking cessation pharmacotherapy (e.g. NRT, varenicline, cytisine, nortriptyline \[including if it is used for a different indication\], and amitriptyline \[as it converts to nortriptyline\].
• • They are currently enrolled in another vaping cessation programme/trial.