Ramadan Fasting Outcomes in Patients With Secondary Adrenal Insufficiency Before and After the Treatment of Hypotension.

Launched by HOPITAL LA RABTA · Feb 12, 2025

Keywords

ClinConnect Summary

This clinical trial is exploring how treating low blood pressure (hypotension) with a medication called fludrocortisone may help patients with secondary adrenal insufficiency safely fast during Ramadan. Previous studies have shown that fasting can lead to complications like dehydration for these patients, especially if they already have low blood pressure. By giving patients fludrocortisone before Ramadan 2025, the researchers want to see if this treatment reduces complications and allows them to fast more safely compared to previous years.

To participate in this study, you need to be over 18 years old and have been on glucocorticoid treatment for secondary adrenal insufficiency for more than a year. You must also be willing to fast during Ramadan 2025 and have participated in a related study in 2023. If you join, you will take fludrocortisone daily before Ramadan, and then researchers will track any complications you experience while fasting. It's important to note that certain medical conditions, like severe heart or kidney issues, may prevent you from participating.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients aged over 18 years
• • Secondary adrenal insufficiency patients
• • Substituted with glucocorticoids for more than one year.
• • Participated in the former study in 2023.
• • Willing to fast during the month of Ramadan 2025.
• Exclusion Criteria:
• • cardiac, respiratory, hepatic or renal insufficiency (creatinine clearance \< 60 ml/min/1.73m2), advanced neoplasia, undernutrition, diabetes insipidus, diabetes mellitus, neuro-psychiatric disease, infectious or chronic inflammatory disease, hyperthyroidism, uncontrolled hypothyroidism, alcoholism, diuretic intake, glucocorticoid treatment for purposes other than substitution, enzyme inducers, pregnancy, breastfeeding.
• • consent withdrawn, study discontinuation.