Novel Risk Prediction Approaches for the Primary Prevention of Cardiovascular Diseases in Italy: the CVRISK-IT Trial (CVRISK-IT)

Launched by IRCCS POLICLINICO S. DONATO · Feb 12, 2025

Keywords

ClinConnect Summary

The CVRISK-IT trial is studying whether adding genetic and imaging information can help predict the risk of developing heart-related diseases in people who are generally healthy but may be at low to moderate or high risk. The goal is to see if this extra information, combined with lifestyle advice and medical treatment, can improve the prevention of cardiovascular diseases (CVD) in Italy and beyond. By gathering health information and biological samples from participants, researchers hope to learn more about the causes of chronic diseases and develop better ways to diagnose and prevent them in the future.

To participate in this study, individuals must be between 40 and 80 years old and should not have a history of heart disease or diabetes. Participants will be recruited from selected healthcare centers in Italy and must agree to provide informed consent. They should also have access to email and the internet. If you join the trial, you will be contributing to important research that could benefit many people at risk of heart diseases, and you may help shape future health interventions.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age: 40-80 years
• • Apparently healthy individuals without previous medical history of CVD or diabetes (based on medical diagnosis)
• • Participant recruitment arranged only at selected IRCCS (and associated Spokes) as part of the 'Rete Cardiologica'
• • Participants must have signed the Informed Consent and Data Privacy Treatment forms
• • Participants must have a personal e-mail address and internet connection
• Exclusion Criteria:
• • Age ≤40 or ≥80 years
• • Individuals have previous medical history related to CVD (e.g., heart failure, congenital heart disorder, coronary heart disease) based on medical diagnosis
• • Candidates have previously participated in clinical studies of 'Rete Cardiologica' (e.g., PREVITAL)
• • Medical diagnosis of mental disorders
• • Pregnancy based on self-reported information
• • Previous history of type 1 or type 2 diabetes (based on medical diagnosis)
• • Oncology patients (based on physician indication)