Lifestyle Intervention in the Memory Clinics of General and Academic Hospitals Trial

Launched by MAASTRICHT UNIVERSITY MEDICAL CENTER · Feb 12, 2025

Keywords

ClinConnect Summary

The LIGHT trial is studying how lifestyle changes can help older adults who have early signs of memory problems, known as subjective cognitive decline (SCD) or mild cognitive impairment (MCI). The goal is to see if a tailored lifestyle intervention can reduce the risk of developing dementia. In this study, 300 participants aged 50 and older will be divided into two groups: one group will receive personalized coaching on healthy habits, along with support to help them manage their lifestyle changes, while the other group will get general health advice for a year.

To be eligible for this trial, participants must be at least 50 years old and have either SCD or MCI, along with two or more factors that can be changed to reduce dementia risk. However, individuals with a dementia diagnosis or certain other health conditions cannot participate. Those who join the trial can expect to receive guidance on improving their health and memory over the year. This study is currently recruiting participants, and it aims to help us understand if lifestyle changes can truly make a difference in memory and cognitive health as we age.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • ≥50 years of age at pre-screening;
• • Having a diagnosis of SCD or MCI;
• • Presence of ≥ 2 modifiable risk factors for dementia.
• Exclusion Criteria:
• • Having a diagnosis of dementia;
• • Insufficient understanding of the Dutch language;
• • Conditions affecting safe and continuous engagement in the intervention (e.g. under treatment for current malignant diseases, major psychiatric disorders (e.g. major depression, psychosis, bipolar disorder), other conditions preventing co-operation as judged by the local study nurse or consulted physician at the local study site;
• • Participation in any other research intervention trial at time of pre-screening and throughout the study period.