Screening for Hepatitis Virus B Protein X (HBx) in Colitis-associated Cancer (CAC)

Launched by IRCCS SAN RAFFAELE · Feb 12, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at a specific protein called HBx, which comes from the Hepatitis B Virus (HBV). Researchers have found that this protein appears more often in patients with Ulcerative Colitis (UC) than in healthy people or those with other similar conditions. They believe that HBx may lead to inflammation in the colon, which could increase the risk of developing colitis-associated colorectal cancer (CAC). The study will analyze tissue samples from patients diagnosed with CAC to see if HBx plays a role in this process.

To be eligible for this trial, participants must be adults (18 years or older) who have been diagnosed with CAC, colorectal cancer, diverticulitis, or Crohn's disease, and who have not had a history of Hepatitis B infection. Participants will need to sign consent for their clinical data to be used in research. The trial is still in the planning stages and is not yet recruiting participants. If you or someone you know fits these criteria, this study could provide valuable insights into the connection between HBx and cancer in patients with colitis.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • adult patients (age ≥18 years), both male and female, diagnosed with CAC, CRC, diverticulitis, IC or CD who had previously undergone endoscopic biopsy or surgical resection, according to standard clinical practice (from 2021 to 2024);
• • patients with no documented history of HBV infection;
• • patients who had already signed the informed consent authorizing the use of their clinical data for future scientific research.
• Exclusion Criteria:
• • patients under 18 years of age;
• • adult patients (age ≥18 years), both male and female diagnosed with CAC, CRC, diverticulitis, IC or CD with a documented history of HBV infection;
• • patients who have not signed the informed consent authorizing the use of their clinical data for future scientific research.