Familial Breast Cancer in China

Launched by CANCER INSTITUTE AND HOSPITAL, CHINESE ACADEMY OF MEDICAL SCIENCES · Feb 13, 2025

Keywords

ClinConnect Summary

This clinical trial, titled "Familial Breast Cancer in China," is focused on studying breast cancer patients who have a family history of the disease and specific genetic changes. The researchers will look at medical records and follow-up information from patients diagnosed and treated in various hospitals in China between January 1, 2015, and December 31, 2024. The goal is to understand the characteristics of these patients, how they were diagnosed and treated, and their survival outcomes. By analyzing this data, the study aims to identify important factors that influence diagnosis and treatment for those with hereditary breast cancer.

To be eligible for this study, participants must be female patients with inherited breast cancer linked to genetic changes, such as mutations in the BRCA1 or BRCA2 genes. They should not have any serious organ issues and need to have a good performance status, meaning they can carry out daily activities without significant problems. Unfortunately, those with severe organ dysfunction, other cancers (unless treated and cured for at least five years), or certain health conditions will not be able to participate. While the study is not yet recruiting participants, it aims to provide valuable insights into familial breast cancer and improve care for future patients.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Familial inherited breast cancer with genetic variants, including but not limited to mutations in the BRCA1, BRCA2, TP53, and PALB2 genes
• • The patient had no major organ dysfunction
• • ECOG score 0-1
• Exclusion Criteria:
• • There are serious dysfunction of vital organs (heart, liver, kidney)
• • Patients with other malignancies, except cured non-melanoma skin cancer, cervical carcinoma in situ and other tumors that have been cured for at least 5 years
• • In other acute infectious disease or chronic infectious disease activity period
• • A history of uncontrolled seizures, central nervous system disorders, or mental disorders