Impact of Pain From Injectables Antiretroviral Treatments in HIV-1 Patients Based on the Injection Site (Ventrogluteal or Dorsogluteal) and the Use or Non-use of Virtual Reality Headset

Launched by CENTRE HOSPITALIER RÉGIONAL D'ORLÉANS · Feb 18, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how much pain patients with HIV-1 feel from injectable antiretroviral treatments, specifically looking at two different injection sites: the dorsogluteal (the upper outer part of the buttock) and the ventrogluteal (the side of the hip). The trial also examines whether using a virtual reality headset during the injection can help reduce pain. Participants will receive four injections in different sequences, helping researchers understand which method is less painful.

To participate, individuals must be at least 18 years old, have HIV-1 that is under control, and be scheduled to receive injectable treatments with Cabotegravir® and Rilpivirine®. Those currently on other injectable antiretroviral treatments or with certain medical conditions, such as epilepsy or severe motion sickness, won't be eligible. If chosen, participants can expect to try different injection methods and share their pain experiences, helping to improve treatment for others in the future. The study is currently recruiting participants, and all genders are welcome.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patient aged at least 18 years;
• • Patient infected with HIV-1;
• • Patient virologically controlled (VL \< 50 copies/ml);
• • Patient scheduled to receive treatment with cabotegravir and rilpivirine (naïve patients) or currently on injectable cabotegravir and rilpivirine, prescribed by their referring physician.
• Exclusion Criteria:
• • Patient(s) on another injectable antiretroviral treatment;
• • Patient participating in another clinical trial with medication;
• • Patient(s) with epilepsy;
• • Patient on antidepressant treatment;
• • Patient(s) with psychiatric or behavioral disorders;
• • Patient(s) with a history of dizziness and motion sickness that prevents the use of virtual reality headset;
• • Patient(s) with visual and hearing impairments that prevent the use of virtual reality headset;
• • Patient(s) deprived of liberty, under guardianship or under curatorship;
• • Patient(s) not affiliated with a social security scheme;
• • Pregnant or breastfeeding women.