A Phase 3 Study to Assess the Efficacy, Safety, and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participants With Inadequately-controlled Chronic Rhinosinusitis With Nasal Polyps

Launched by SANOFI · Feb 14, 2025

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ClinConnect Summary

This clinical trial is testing a new treatment called itepekimab for people with chronic rhinosinusitis with nasal polyps (CRSwNP), a condition that causes inflammation and swelling in the nasal passages, often leading to difficulty breathing and loss of smell. The study aims to find out if itepekimab can help manage symptoms better than a placebo (a harmless dummy treatment) when added to standard nasal steroid sprays. Participants in the study will be monitored over a period of up to 76 weeks, which includes a 52-week treatment phase and follow-up care.

To be eligible for this trial, participants must be 18 years or older and have had CRSwNP for at least a year, with ongoing symptoms that require treatment. Important factors include having had previous surgery for nasal polyps or worsening symptoms in the last two years. Participants will attend nine in-person visits and receive regular phone check-ins to assess their health and treatment response. It’s important for potential participants to know that they cannot have certain medical conditions or recent treatments that might interfere with the study. If you or someone you know is struggling with CRSwNP and is interested in participating, this might be a valuable opportunity to receive new treatment options.

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Eligibility criteria

• Inclusion Criteria:
• • Participants must be 18 years of age or older.
• • Participants with a history of chronic rhinosinusitis with nasal polyps (CRSwNP) for at least 1 year prior to screening
• * Participants must have at least one of the following features:
• • Prior sinonasal surgery for nasal polyps (NP).
• • Worsening symptoms of chronic rhinosinusitis (CRS) requiring treatment with systemic corticosteroid(s) (SCS) within the prior 1 year before screening (Visit 1).
• • An endoscopic bilateral Nasal Polyp Score (NPS) of at least 5 out of maximum score of 8 (with a minimum score of 2 in each nasal cavity) at screening and randomization.
• * Ongoing symptoms (for at least 12 weeks before Visit 1) of:
• • Nasal congestion/blockade/obstruction with moderate or severe (symptom severity score 2 or 3) at Visit 1 and a weekly average severity of greater than 1 in the week before randomization (Visit 2), AND
• • At least one of the following two symptoms: loss of smell or rhinorrhea (anterior/posterior).
• * A female participant is eligible to participate if she is not pregnant or breastfeeding, and at least 1 of the following conditions applies:
• • Is not a women of childbearing potential (WOCBP), OR
• • Is a WOCBP and agrees to use a contraceptive method that is highly effective, with a failure rate of \<1% during the study (at a minimum until 20 weeks after the last dose of study intervention).
• Exclusion Criteria:
• Participants are excluded from the study if any of the following criteria apply:
• • Participants with a history of clinically significant renal, hepatic, metabolic, neurologic, hematologic, ophthalmologic, respiratory (excluding those with asthma and aspirin-exacerbated respiratory disease (AERD) which may be included in the study), gastrointestinal, cardiovascular, cerebrovascular, or other significant medical illness or disorder, which, in the judgment of the Investigator, could interfere with the study or require treatment that might interfere with the study.
• • Participants who are currently smoking tobacco and/or vaping, or participants in whom smoking/vaping cessation has occurred \<6 months prior to Screening (Visit 1). Nicotine replacement therapy and/or noninhaled tobacco product use are not considered current smoking of tobacco.
• • Participants meet any contraindications for mometasone furoate nasal spray (MFNS) such as hypersensitivity to MFNS or any of its components; or participants with uncontrolled opportunistic infections.
• • Participants with a history of a severe systemic hypersensitivity reaction to a mAb.
• • Participants with conditions/concomitant diseases making them non-evaluable at Visit 1 or for the primary efficacy endpoint.
• • Participants with nasal cavity malignant tumor and benign tumors (eg, papilloma, blood boil etc).
• • Participants with severe uncontrolled asthma with history of 2 and/or more exacerbations, requiring SCS or 1 hospitalization requiring SCS in the past year.
• • History of concomitant lung disease (other than asthma, eg, COPD, interstitial lung disease) which in the opinion of the Investigator could interfere with performance and interpretation of spirometry.
• • Participants treated with intranasal corticosteroid(s) (INCS) (MFNS is permitted), intranasal emitting devices/stents, nasal spray using exhalation delivery system such as XhanceTM during the screening period. In Japan and China INCS other than MFNS are permitted.
• • Participants who have undergone any sinus intranasal surgery (including polypectomy) within 6 months before Visit 1.
• • Participants who received SCS 1 month prior to Screening (Visit 1) or during the screening period (between Visit 1 and Visit 2).
• • Known allergy to itepekimab or its excipients, or any drug or other allergy that, in the opinion of the Investigator, contraindicates participation in this study.
• • The above information is not intended to contain all considerations relevant to a participant's potential participation in a clinical trial.